Xenoestrogens in Relation to Mammographic Breast Density - a Marker of Breast Cancer Risk - in Postmenopausal Women.
Amy Trentham-Dietz, PhD, University of Wisconsin
Bisphenol-A (BPA) is widely accepted as an endocrine disruptor, but evidence is lacking to establish BPA as a breast carcinogen. Human studies of the health effects of BPA are scarce, and studies of BPA are largely limited to laboratory studies. BPA is present in plastic consumer products including canned food linings and #7 polycarbonate plastics. According to recent NHANES data, human exposure as measured in urine is widespread (about 93% of people aged >5) and more common in females than males (Calafat EHP 2008). To evaluate the association between BPA exposure and breast cancer risk in adult women, we recruited 264 postmenopausal women from mammography screening clinics in Dane County, Wisconsin. We examined the cross-sectional association of circulating serum levels of three phenols including BPA with mammographic breast density—a strong marker for breast cancer risk. Results from this study will be described in this presentation. Relations between the three phenols and breast density will be presented as well as relations between several sex hormones including estradiol with breast density. Results provide preliminary evidence to guide additional studies on the effects of xenoestrogens like BPA on the risk of breast cancer.
Supported by DOD BC062649, Komen FAS0703857, and NIH R03 CA139548.